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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-KTI-2338
KTI-2338

Chemical Structure : KTI-2338

CAS No.: 2248155-16-8

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KTI-2338 (KTI2338, KTI 2338)

货号: PC-25943Not For Human Use, Lab Use Only.

KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1.
    KTI-2338 decreases Activin A-stimulated pSMAD1/5/9 signaling in FOP fibroblasts.
    KTI-2338 (223 nM) significantly reduces ID1 and ID2 expression in FOP fibroblasts.
    KTI-2338 successfully reduces osteogenic gene expression in both fibroblasts and transdifferentiated osteoblast-like cells.

    物理化学性质&存储条件

    分子量 447.52
    分子式 C24H26FN7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-fluoro-6-methoxy-4-(6-(3-(4-methylpiperazin-1-yl)azetidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

    参考文献

    1. Rosenberg NM, et al. Pharmaceutics. 2025 Dec 10;17(12):1590.

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