| Cat. No. |
Product Name |
Information |
| PC-61454 |
TP-0427736
ALK5 inhibitor
|
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3. |
| PC-61453 |
ALK5-IN-16i
ALK5 inhibitor
|
ALK5-IN-16i is a potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3. |
| PC-61448 |
IN-1233 phosphate
ALK5 inhibitor
|
IN-1233 phosphate is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery. |
| PC-61447 |
IN-1233
ALK5 inhibitor
|
IN-1233 is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery. |
| PC-61446 |
EW-7195
ALK5 inhibitor
|
EW-7195 (EW7195) is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α. |
| PC-60916 |
San78-130
ALK1 inhibitor
|
San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277. |
| PC-60915 |
L-783277
ALK1 inhibitor
|
L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM. |
| PC-60770 |
ML347
ALK1/ALK2 inhibitor
|
ML347 (VU0469381, LDN193719) is a potent, selective BMP receptor ALK1/ALK2 inhibitor with IC50 of 46/32 nM, has no affinity for ALK3/4/5/6, blocks the phosphorylation of Smad1/5 by TGF-β1. |
| PC-60769 |
VU 0465350
ALK3 inhibitor
|
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM. |
| PC-60768 |
VU 0364849
ALK3 inhibitor
|
VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM. |
| PC-70054 |
IN-1130
ALK5 inhibitor
|
IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM. |
| PC-70053 |
GW-6604
ALK5 inhibitor
|
GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay. |
