TP-0427736 |CAS:864374-00-5 Probechem Biochemicals

Chemical Structure : TP-0427736

CAS No.: 864374-00-5

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TP-0427736 (TP0427736)

货号: PC-61454Not For Human Use, Lab Use Only.

TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥4580	In stock
50 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
TP-0427736 inhibits Smad2/3 phosphorylation in A549 cells (IC50=8.7 nM) and decreases the growth inhibition of human outer root sheath cells.
TP-0427736 significantly decreases Smad2 phosphorylation in mouse skin after topical application, may serves as a potential new therapy for AGA.

物理化学性质&存储条件

分子量	298.382
分子式	C14H10N4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole

参考文献

1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.

2. Naruse T, et al. Pharmacol Rep. 2017 Jun;69(3):485-491.

TP-0427736 (TP0427736)

生物&药学活性

物理化学性质&存储条件

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TP-0427736 (TP0427736)

生物&药学活性

物理化学性质&存储条件

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