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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-GW-6604
GW-6604

Chemical Structure : GW-6604

CAS No.: 452342-37-9

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GW-6604 (GW6604, GW 6604)

货号: PC-70053Not For Human Use, Lab Use Only.

GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.

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10 mg ￥1180 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW-6604 (GW6604) is a TGF-beta signaling pathway inhibitor that tagets ALK5, inhibits autophosphorylation of ALK5 with an IC50 of 140 nM in vitro and inhibits TGF-beta-induced transcription of PAI-1 (IC50=500 nM) in a cellular assay.
GW-6604 increases liver regeneration in TGF-beta-overexpressing mice at 40 mg kg(-1) p.o.

物理化学性质&存储条件

分子量 298.34
分子式 C19H14N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine

参考文献

1. de Gouville AC, et al. Br J Pharmacol. 2005 May;145(2):166-77.

2. de Gouville AC, et al. Drug News Perspect. 2006 Mar;19(2):85-90.

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