VU 0364849 |CAS:1206711-14-9 Probechem Biochemicals

Chemical Structure : VU 0364849

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VU 0364849 (VU 0364849;DMH2;DMH 2)

货号: PC-60768Not For Human Use, Lab Use Only.

VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.

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25 mg		Get quote
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250 mg		Get quote
1 g		Get quote

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生物&药学活性

VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
VU 0364849 also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.
VU 0364849 blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.

物理化学性质&存储条件

分子量	451.53
分子式	C27H25N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine

参考文献

1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129.

3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256.

VU 0364849 (VU 0364849;DMH2;DMH 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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VU 0364849 (VU 0364849;DMH2;DMH 2)

生物&药学活性

物理化学性质&存储条件

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