L-783277 |CAS:791807-02-8 Probechem Biochemicals

首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-L-783277

Chemical Structure : L-783277

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L-783277 (L 783277;L783277)

货号: PC-60915Not For Human Use, Lab Use Only.

L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM.

物理化学性质&存储条件

分子量	364.39
分子式	C19H24O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

参考文献

1. Liniger M, et al. ACS Med Chem Lett. 2010 Oct 20;2(1):22-7.

2. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.

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L-783277 (L 783277;L783277)

生物&药学活性

物理化学性质&存储条件

参考文献

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L-783277 (L 783277;L783277)

生物&药学活性

物理化学性质&存储条件

参考文献

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