ML347 (VU0469381, LDN193719) | ALK1/ALK2 inhibitor | Probechem Biochemicals

Chemical Structure : ML347

CAS No.: 1062368-49-3

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ML347 (LDN193719, VU0469381, ML-347)

货号: PC-60770Not For Human Use, Lab Use Only.

ML347 (VU0469381, LDN193719) is a potent, selective BMP receptor ALK1/ALK2 inhibitor with IC50 of 46/32 nM, has no affinity for ALK3/4/5/6, blocks the phosphorylation of Smad1/5 by TGF-β1.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
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生物&药学活性

ML347 (VU0469381, LDN193719) is a potent, selective BMP receptor ALK1/ALK2 inhibitor with IC50 of 46/32 nM, has no affinity for ALK3/4/5/6, blocks the phosphorylation of Smad1/5 by TGF-β1.

物理化学性质&存储条件

分子量	352.397
分子式	C22H16N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

参考文献

1. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

2. Engers DW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

ML347 (LDN193719, VU0469381, ML-347)

生物&药学活性

物理化学性质&存储条件

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ML347 (LDN193719, VU0469381, ML-347)

生物&药学活性

物理化学性质&存储条件

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