IN-1130 | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : IN-1130

CAS No.: 868612-83-3

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IN-1130 (IN1130, IN 1130)

货号: PC-70054Not For Human Use, Lab Use Only.

IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

IN-1130 is a potent, highly selective ALK5 inhibitor, inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM.
IN-1130 is highly selective in a panel of 27 serine/threonine and tyrosine kinases including p38α.
IN-1130 decreases levels of TGF-beta1 mRNA, type I collagen mRNA, and pSmad2, compared to UUO control rats.
IN-1130 inhibits renal fibrosis in obstructive nephropathy in vivo models.

物理化学性质&存储条件

分子量	420.47
分子式	C25H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 3-[[4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]- (9CI)

参考文献

1. Moon JA, et al. Kidney Int. 2006 Oct;70(7):1234-43.

2. Ryu JK, et al. J Sex Med. 2009 May;6(5):1284-96.

3. Park CY, et al. Cancer Lett. 2014 Aug 28;351(1):72-80.

IN-1130 (IN1130, IN 1130)

生物&药学活性

物理化学性质&存储条件

参考文献

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IN-1130 (IN1130, IN 1130)

生物&药学活性

物理化学性质&存储条件

参考文献

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