Necrostatin-34 | RIPK1 inhibitor | Probechem Biochemicals

Chemical Structure : Necrostatin-34

CAS No.: 375835-43-1

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Necrostatin-34 (Nec-34, Necrostatin 34)

货号: PC-73007Not For Human Use, Lab Use Only.

Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM.

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10 mg	￥2280	In stock
25 mg	￥3780	In stock
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生物&药学活性

Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM.
Nec-34 effectively inhibited necroptosis induced by the addition of AP20187 and zVAD.fmk, inhibited the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation.
Nec-34 showed no effect on the early activation signatures of NF-κB and MAPK pathways, including phosphorylation of IKKα/β, p65, p38, JNK, MK2, IκBα, and degradation of IκBα.
Nec-34 inhibited the activity of RIPK1 (IC50=5.5 uM, 111 mM ATP) and disrupted the formation of complex II.
Nec-34 inhibits RIPK1 kinase through a mechanism distinct from that of Nec-1s.

物理化学性质&存储条件

分子量	384.48
分子式	C18H16N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide

参考文献

1. Huyan Meng, et al. Cell Discov. 2021 Jun 1;7(1):41.

Necrostatin-34 (Nec-34, Necrostatin 34)

生物&药学活性

物理化学性质&存储条件

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Necrostatin-34 (Nec-34, Necrostatin 34)

生物&药学活性

物理化学性质&存储条件

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