AS3334034 | RIPK2 inhibitor | Probechem Biochemicals

Chemical Structure : AS3334034

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AS3334034 (AS 3334034)

货号: PC-47116Not For Human Use, Lab Use Only.

AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively.

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生物&药学活性

AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively.
AS3334034 concentration-dependently inhibited MDP-induced NF-κB activation in HCT116 cells with IC50 of 4.4 nM.
AS3334034 displays >480-fold selectivity against a great panel of kinases, only partially inhibits several kinase activities at 1 uM, such as discoidin domain receptor and ephrin receptor.
AS3334034 (3-30 mg/kg, p.o.) dose-dependently inhibited MDP-induced increase in plasma MCP-1 level in rats.
AS3334034 (10 mg/kg, once daily, p.o.) significantly reduced urinary protein excretion and prevented the development of glomerulosclerosis and tubulointerstitial fibrosis in uninephrectomized adriamycin-induced CKD rats.

物理化学性质&存储条件

分子量	374.459
分子式	C18H22N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-6-(2-methylpropane-2-sulfonyl)-N-(4-methyl-1H-pyrazol-3-yl)quinolin-4-amine

参考文献

1. Wada Y, et al. J Pharmacol Exp Ther. 2020 Sep;374(3):428-437.

AS3334034 (AS 3334034)

生物&药学活性

物理化学性质&存储条件

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AS3334034 (AS 3334034)

生物&药学活性

物理化学性质&存储条件

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