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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-ZJU-37
ZJU-37

Chemical Structure : ZJU-37

CAS No.: 2408587-59-5

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ZJU-37 (ZJU37)

货号: PC-38621Not For Human Use, Lab Use Only.

ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM.
    ZJU-37 promotes oligodendrocyte progenitor cells (OPCs) proliferation in vitro with higher efficacy than Nec-1s, enhances remyelination in vivo.
    ZJU-37 promotes transcription of PDGFRα and proliferation of OPCs via NF-κB.

    物理化学性质&存储条件

    分子量 323.708
    分子式 C14H11ClFN3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-((7-chloro-6-fluoro-1H-indol-3-yl)methyl)-3-methyl-2,4-dioxoimidazolidine-1-carbaldehyde

    参考文献

    1. Xiao-Ru Ma, et al. Cell Death Discov. 2022 Apr 1;8(1):147.

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