欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Apoptosis-Receptor Interacting Protein Kinase (RIPK)-Flizasertib
Flizasertib

Chemical Structure : Flizasertib

CAS No.: 2268739-68-8

加入收藏

Flizasertib (GDC-8264, GDC8264)

货号: PC-20036Not For Human Use, Lab Use Only.

Flizasertib (GDC-8264) is a potent, selective receptor-interacting protein 1 (RIP1, RIPK1) inhibitor with Kiapp of 0.71 nM.

规格 价格 库存 数量
2 mg ￥3980 In stock
5 mg ￥5980 In stock
10 mg ￥8980 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Flizasertib (GDC-8264) is a potent, selective receptor-interacting protein 1 (RIP1, RIPK1) inhibitor with Kiapp of 0.71 nM.
GDC-8264 more potently inhibits the kinase activity of primate RIP1 (human Kiapp = 0.00071 μM and cyno Kiapp = 0.0013 μM) than rodent orthologs (mouse Kiapp = 4.5 μM and rat Kiapp > 10 μM).
GDC-8264 blocks RIP1 autophosphorylation but did not affect RIP1 protein stability or TNF-stimulated NF-κB and MAPK activation and the induction of gene expression.
GDC-8264 potently inhibits cell death in immortalized human HT29 cells with IC50 of 7.8 nM.
GDC-8264 inhibits TBZ-stimulated CCL3, CCL4, and IL-1β production in human whole blood with IC50 of < 2 nM.
GDC-8264 inhibits colon and ileum crypt damage and inflammation in NEMO IEC cKO mice, inhibits TNF plus zVAD (TZ)-driven SIRS (systemic inflammatory response syndrome) mouse model.

物理化学性质&存储条件

分子量 271.30
分子式 C15H14FN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclopropyl[(5S,7S)-7-fluoro-6,7-dihydro-5-phenyl-5H-pyrrolo[1,2-b][1,2,4]triazol-2-yl]methanone

参考文献

1. Patent WO2022212809 A1

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: