Oditrasertib (DNL788, SAR443820)

Chemical Structure : Oditrasertib

CAS No.: 2252271-93-3

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货号: PC-20063Not For Human Use, Lab Use Only.

Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)‐derived microglia.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5280	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)‐derived microglia.

物理化学性质&存储条件

分子量	295.29
分子式	C14H15F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,3-difluoro-2,2-dimethylpropanoyl)-2,3,4,5- tetrahydropyrido[3,4-f][1,4]oxazepine-9-carbonitrile

参考文献

1. Patent WO2018213632 A1.
2. Hincelin-Mery A, et al. Clin Transl Sci. 2024 Jan;17(1):e13690.