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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-GSK840
GSK840

Chemical Structure : GSK840

CAS No.: 2361146-30-5

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GSK840 (GSK'840, GSK-840)

货号: PC-21478Not For Human Use, Lab Use Only.

GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.
GSK840 blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds RIP3 kinase domain with IC50 of 0.9 nM, and inhibits kinase activity with IC50 of 0.3 nM.

物理化学性质&存储条件

分子量 365.43
分子式 C21H23N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate

参考文献

1. Mandal P, et al. Mol Cell. 2014 Nov 20;56(4):481-95.

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