RIPK1 inhibitor SZ-15

Chemical Structure : RIPK1 inhibitor SZ-15

加入收藏

货号: PC-27636Not For Human Use, Lab Use Only.

RIPK1 inhibitor SZ-15 is a potent, selective gut-restricted RIPK1 inhibitor, inhibits necroptosis.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RIPK1 inhibitor SZ-15 is a potent, selective gut-restricted RIPK1 inhibitor, inhibits necroptosis.
SZ-15 effectively inhibited necroptosis in U937 and HT-29 cells at concentrations of 1 nM and 10 nM, respectively
SZ-15 at a concentration of 10 nM almost completely blocked RIPK1, RIPK3, and mixed-lineage kinase domain-like (MLKL) protein phosphorylation induced by necrosis inducers.
SZ-15 suppresses necroptosis in HT-29 and U937 cells through inhibition of the TNF-α/RIPK1/RIPK3/MLKL signaling pathway.
SZ-15 suppresses the pro-necroptosis function of RIPK1 by downregulating the mRNA expression of pro-inflammatory cytokines.
SZ-15 (50 mg/kg) by intragastric administration alleviates DSS-induced ulcerative colitis in vivo.

物理化学性质&存储条件

分子量	913.01
分子式	C50H48N12O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-((3S,3'S)-(piperazine-1,4-diylbis(prop-1-yne-3,1-diyl))bis(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepine-7,3-diyl))bis(1-benzyl-1H-1,2,4-triazole-3-carboxamide)

参考文献

1. Yi-Sheng Zeng, et al. Eur J Pharmacol. 2022 Dec 15:937:175381.