SB415286 | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : SB415286

CAS No.: 264218-23-7

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SB415286 (SB-415286)

货号: PC-49262Not For Human Use, Lab Use Only.

SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
250 mg		Get quote

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生物&药学活性

SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
SB-415286 stimulated glycogen synthesis in human liver cells and induced expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells.
SB-415286 inhibited cellular GSK-3 activity as assessed by activation of glycogen synthase.
SB-415286 protected both central and peripheral nervous system neurones in culture from death induced by reduced PI 3-kinase pathway activity.
SB-415286 reduced the growth of AR-expressing prostate cancer cell lines.

物理化学性质&存储条件

分子量	359.722
分子式	C16H10ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione

参考文献

1. Coghlan MP, et al. Chem Biol. 2000 Oct;7(10):793-803.

2. Cross DA, et al. J Neurochem. 2001 Apr;77(1):94-102.

3. Mazor M, et al. Oncogene. 2004 Oct 14;23(47):7882-92.

SB415286 (SB-415286)

生物&药学活性

物理化学性质&存储条件

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SB415286 (SB-415286)

生物&药学活性

物理化学性质&存储条件

参考文献

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