GSK-3β inhibitor 47

Chemical Structure : GSK-3β inhibitor 47

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货号: PC-20114Not For Human Use, Lab Use Only.

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.
GSK-3β inhibitor 47 significantly lowered levels of phosphorylated tau in triple-transgenic mouse Alzheimer's disease models.

物理化学性质&存储条件

分子量	414.47
分子式	C23H22N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-methylmorpholino)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide

参考文献

1. Richard A. et al. J. Med. Chem. 2023