MMBO | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : MMBO

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MMBO (GSK-3 inhibitor MMBO)

货号: PC-63357Not For Human Use, Lab Use Only.

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.

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生物&药学活性

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
MMBO inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD.
MMBO suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models.

物理化学性质&存储条件

分子量	338.381
分子式	C18H14N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole

参考文献

1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40.

MMBO (GSK-3 inhibitor MMBO)

生物&药学活性

物理化学性质&存储条件

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MMBO (GSK-3 inhibitor MMBO)

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物理化学性质&存储条件

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