LY2090314 | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : LY2090314

CAS No.: 603288-22-8

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LY2090314 (LY 2090314)

货号: PC-20193Not For Human Use, Lab Use Only.

LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively.
LY2090314 stimulated TCF/LEF TOPFlash reporter activity, stabilized β-catenin and elevated the expression of Axin2 in a panel of melanoma cell lines at nM potency.
LY2090314 exhibited cytotoxicity against melanoma cell lines in vitro with IC50 of 10 nM, but not other solid tumor cell lines (IC50 >10 uM).
LY2090314 elevates Axin2 gene expression after a single dose and produces tumor growth delay in A375 melanoma xenografts with repeat dosing.

物理化学性质&存储条件

分子量	512.55
分子式	C28H25FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione

参考文献

1. Atkinson JM, et al. PLoS One. 2015 Apr 27;10(4):e0125028.

2. Rizzieri DA, et al. Leuk Lymphoma. 2016 Aug;57(8):1800-6.

LY2090314 (LY 2090314)

生物&药学活性

物理化学性质&存储条件

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LY2090314 (LY 2090314)

生物&药学活性

物理化学性质&存储条件

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