Tideglusib (NP031112, NP-12)

Chemical Structure : Tideglusib

CAS No.: 865854-05-3

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货号: PC-49290Not For Human Use, Lab Use Only.

Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2380	In stock
250 mg		Get quote

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生物&药学活性

Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM.
Tideglusib (NP031112) is a potent anti-inflammatory and neuroprotective agent against KA-induced in vivo excitotoxicity.
Tideglusib (NP031112) inhibits glutamate-induced glial activation and protects cortical neurons from cell death in vitro.
Tideglusib (NP031112) attenuates glutamate-induced excitotoxic glial activation and neuronal damage.

物理化学性质&存储条件

分子量	334.393
分子式	C19H14N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione

参考文献

1. Luna-Medina R, et al. J Neurosci. 2007 May 23;27(21):5766-76.

2. Domínguez JM, et al. J Biol Chem. 2012 Jan 6;287(2):893-904.

3. Serenó L, et al. Neurobiol Dis. 2009 Sep;35(3):359-67.