YT-6-2 | p62/SQSTM1 agonist | Probechem Biochemicals

Chemical Structure : YT-6-2

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YT-6-2 (YT 6-2)

货号: PC-23449Not For Human Use, Lab Use Only.

YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.

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生物&药学活性

YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy.
YT-6-2 induces the biogenesis and recruitment of autophagic membranes to intracellular bacteria via SQSTM1, leading to lysosomal degradation.
YT-6-2 enhances host innate immunity against Mtb and other pathogens via SQSTM1-mediated xenophagy.
YT-6-2 (5-10 uM) dramatically inhibits the growth rate of Mtb in Mtb-infected BMDMs in CFU assays.
YT-6-2 (i.p. 20 mg/kg) enhance xenophagy-mediated host defense against pathogens in mice.
YT-6-2 inhibits the production of proinflammatory mediators in vitro and in vivo.
YT-6-2 also could be used as p62/SQSTM1 ligand for AUTOTAC design.

物理化学性质&存储条件

分子量	459.49
分子式	C25H27F2NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(3,4-bis((4-fluorobenzyl)oxy)phenoxy)-3-((2-hydroxyethyl)amino)propan-2-ol

参考文献

1. Yoon Jee Lee, et al. Autophagy. 2022 Dec;18(12):2926-2945

YT-6-2 (YT 6-2)

生物&药学活性

物理化学性质&存储条件

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YT-6-2 (YT 6-2)

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