Autophagy activator SQ-1 (STOCK1N-57534)

Chemical Structure : Autophagy activator SQ-1

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货号: PC-27710Not For Human Use, Lab Use Only.

Autophagy activator SQ-1 (STOCK1N-57534) is a small-molecule activator of autophagy, engages the prototypical SAR protein p62/SQSTM1 (sequestosome-1), binds ZZ domain of p62 and induces p62 oligomerisation.

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

Autophagy activator SQ-1 (STOCK1N-57534) is a small-molecule activator of autophagy, engages the prototypical SAR protein p62/SQSTM1 (sequestosome-1), binds ZZ domain of p62 and induces p62 oligomerisation.
SQ-1 induces autophagy in a p62 ZZ domain- and oligomerisation-dependent manner.
SQ-1 induces autophagy by sensitising p62 to oxidation by mitochondria-derived ROS.
SQ-1 rescues survival of NPC1 cells by activating autophagy/mitophagy.
SQ-1 enhances the flux through p62-dependent selective autophagy pathway.

物理化学性质&存储条件

分子量	529.98
分子式	C29H24ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3R,3'S,3a'S,6a'R)-3'-benzyl-6-chloro-7-methyl-2,4',6'-trioxo-2',3',3a',4',6',6a'-hexahydro-5'H-spiro[indoline-3,1'-pyrrolo[3,4-c]pyrrol]-5'-yl)phenyl acetate

参考文献

1. Panek J, et al. J Biol Chem. 2026 Aug 10:113430.

2. George Kelly, et al. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7.