Autophagy activator MG-1

Chemical Structure : Autophagy activator MG-1

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货号: PC-28714Not For Human Use, Lab Use Only.

Autophagy activator MG-1 is a bifunctional small molecule autophagy activator / inducer that enhances the removal of damaged mitochondria through autophagy, shows autophagy-inducing activity under conditions of mitochondrial stress.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Autophagy activator MG-1 is a bifunctional small molecule autophagy activator / inducer that enhances the removal of damaged mitochondria through autophagy, shows autophagy-inducing activity under conditions of mitochondrial stress.
MG-1 does not function as a constitutive autophagy activator but instead exhibits stress-dependent activity that is selectively enhanced under conditions of mitochondrial dysfunction.
MG-1 interacts with MitoNEET and LC3 in cells.
MG-1 activates autophagy preferentially under conditions of mitochondrial dysfunction, rather than through nonspecific induction.
MG-1 modulates AMPK/ULK1-associated autophagy signaling.
MG-1 improves locomotor performance in a danio rerio model of MPTP-induced mitochondrial dysfunction.

物理化学性质&存储条件

分子量	696.77
分子式	C34H40N4O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(1-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)-1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide

参考文献

1. Ozhiganov RM, et al. Adv Sci (Weinh). 2026 Oct 29:e78570.