| Cat. No. |
Product Name |
Information |
| PC-45633 |
Hemin
CLEC-2 agonist, HO-1 inducer
|
Hemin is an iron-containing porphyrin as heme oxygenase (HO)-1 inducer, also is a CLEC-2 agonist that induces CLEC-2-mediated platelet aggregation. |
| PC-42080 |
SMER28
VCP/p97 activator
|
SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97. |
| PC-42248 |
STF-62247
Autophagy inducer
|
STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells. |
| PC-45515 |
SMER-18
Autophagy inducer
|
SMER-18 is a small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein. |
| PC-28578 |
TFEB activator 3
TFEB activator
|
TFEB activator 3 is a brain penetrant small molecule activator of transcription factor EB (TFEB), promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway. |
| PC-28577 |
TFEB activator 2
TFEB activator
|
TFEB activator 2 is a brain penetrant small molecule activator of transcription factor EB (TFEB), promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway. |
| PC-28576 |
TFEB activator 1
TFEB activator
|
TFEB activator 1 is an orally effective, mTOR-independent activator of transcription factor EB (TFEB), promotes the nuclear translocation of Flag-TFEB with EC50 of 2.2 uM, enhances autophagy without inhibiting the mTOR pathway. |
| PC-27850 |
Hydroxychloroquine
Autophagy inhibitor, TLR7/9 inhibitor
|
Hydroxychloroquine is a synthetic antimalarial drug that inhibits autophagy, also inhibits TLR7 and TLR9 signaling, also inhibits peptidyl arginine deiminase 4 (PAD4). |
| PC-27583 |
CUR5g
Autophagy inhibitor
|
CUR5g is a novel potent, specific autophagy inhibitor, selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion, blocks the recruitment of syntaxin 17 (STX17) to autophagosomes via a UVRAG-dependent mechanism. |
| PC-25554 |
Autophagy inhibitor 5j
Autophagy inhibitor
|
Autophagy inhibitor 5j is a potent late-stage autophagy inhibitor, trigger an ER stress response and interfere with cathepsin D maturation, potentially contributing to altered lysosomal trafficking. |
| PC-25244 |
Autophagy activator AA-20
Autophagy activator
|
Autophagy activator AA-20 is a promising small-molecule autophagy enhancer/ activator, enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans. |
| PC-25236 |
Tat-beclin 1
autophagy inducer,
|
Tat-beclin 1 (Tat-BECN1, Tat-Beclin-1) is a potent, specific inducer of autophagy that interacts with negative regulator of autophagy GAPR-1 (also called GLIPR2). |
