| Cat. No. |
Product Name |
Information |
| PC-24347 |
Trimetazidine
LC 3-KAT inhibitor
|
Trimetazidine is a potent, selective long chain 3-ketoyl coenzyme A thiolase inhibitor with IC50 of 75 nM, inhibit β-oxidation of free fatty acid (FFA). |
| PC-23733 |
Pym-18a
Autophagy inducer
|
Pym-18a is a pyrimidine derivative inducer of autophagy and mitophagy, inhibits ROS generation and prevents apoptosis in Dexamethasone (Dex)-treated osteoblast cells, exhibits osteogenic effect by enhancing the autophagy and PINK1/Parkin mediated mitophagy. |
| PC-23449 |
YT-6-2
p62/SQSTM1 agonist
|
YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy. |
| PC-22903 |
Idroxioleic acid
Sphingomyelin synthase inducer
|
Idroxioleic acid (2-OHOA) is a first-in-class brain-penetrating synthetic hydroxylated lipid, activates sphingomyelin synthase (SMS) expression and regulates membrane-lipid composition and mitochondrial energy production, inducing cancer cell autophagy. |
| PC-22679 |
LC3in-C42
LC3A/B inhibitor
|
LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy. |
| PC-21540 |
RH1115
Autophagy activator
|
RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning. |
| PC-60596 |
Hydroxychloroquine sulfate
|
A synthetic antimalarial drug that inhibits autophagy, also inhibits TLR7 and TLR9 signaling.. |
| PC-45984 |
Cysteamine
|
An agent for the treatment of nephropathic cystinosis and an antioxidant. |
| PC-45983 |
Cysteamine hydrochloride
|
An agent for the treatment of nephropathic cystinosis and an antioxidant. |
| PC-45258 |
Mefloquine hydrochloride
|
A quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. |
