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首页-小分子抑制剂&激动剂-Autophagy-CUR5g
CUR5g

Chemical Structure : CUR5g

CAS No.: 1370032-20-4

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CUR5g (Curcumin derivative 5g)

货号: PC-27583Not For Human Use, Lab Use Only.

CUR5g is a novel potent, specific autophagy inhibitor, selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion, blocks the recruitment of syntaxin 17 (STX17) to autophagosomes via a UVRAG-dependent mechanism.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CUR5g is a novel potent, specific autophagy inhibitor, selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion, blocks the recruitment of syntaxin 17 (STX17) to autophagosomes via a UVRAG-dependent mechanism.
CUR5g does not affect the lysosomal pH and proteolytic function, nor does it disturb cytoskeleton.
CUR5g selectively induces autophagosome accumulation in A-549 cancer cells.
CUR5g causes a late-stage block of autophagy by suppressing the fusion of autophagosome with lysosome. blocks incorporation of syntaxin 17 (STX17) on autophagosomes, does not impair the lysosomal proteolytic function and cytoskeleton.
CUR5g inhibits STX17 targeting to autophagosomes by down-regulating UV radiation resistance-associated gene (UVRAG).
CUR5g inhibits proliferation and migration of A549 cells, but does not induce apoptosis or necrosis.
CUR5g exhibits potent synergistic anticancer effects with cisplatin on A549 cells and inhibits autophagic flux in vivo, with no obvious toxicity to normal HUVECs in vitro or mice in vivo.

物理化学性质&存储条件

分子量 344.41
分子式 C22H20N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3E,5E)-1-methyl-3-(4-hydroxybenzylidene)-5-(3-indolymethylene)-piperidine-4-one

参考文献

1. Chen J, et al. Cell Death Discov. 2022 Oct 31;8(1):435.

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