Pym-18a

Chemical Structure : Pym-18a

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货号: PC-23733Not For Human Use, Lab Use Only.

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生物&药学活性

Pym-18a is a pyrimidine derivative inducer of autophagy and mitophagy, inhibits ROS generation and prevents apoptosis in Dexamethasone (Dex)-treated osteoblast cells, exhibits osteogenic effect by enhancing the autophagy and PINK1/Parkin mediated mitophagy.
Pym-18a ameliorates Dex-induced alteration in osteoblast cell differentiation, viability and mineralization.
Pym-18a protects the osteoblast cells from Dex-induced apoptosis.
Pym-18a suppresses Dex-induced intracellular and mitochondrial ROS generation in osteoblast cells.
Pym-18a attenuates the inhibitory effect of Dex on osteoblast autophagy and mitophagy.
Pym-18a inhibited mTOR protein and prevented the Dex-induced phosphorylation of mTOR.
Pym-18a prevents the Dex-induced bone loss and increased the bone strength in GIOP mice.
Pym-18a modulates autophagy and mitophagy, inhibits mTOR phosphorylation, and protects against apoptosis in glucocorticoid-induced osteoporosis (GIOP) mice.

物理化学性质&存储条件

分子量	593.32
分子式	C25H27Br2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-Bromo-4-(4-bromophenyl)-6-(2,4,5-trimethoxyphenyl) pyrimidin-2-yl) hexanamide

参考文献

1. Khanka S, et al. Biochem Pharmacol. 2025 Jan 10:116751.

Pym-18a

生物&药学活性

物理化学性质&存储条件

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Pym-18a

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物理化学性质&存储条件

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