LC3in-C42

Chemical Structure : LC3in-C42

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货号: PC-22679Not For Human Use, Lab Use Only.

LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.

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生物&药学活性

LC3in-C42 is a potent, covalent and cell-active LC3A/B inhibitor with IC50 of 7.6 nM in AlphaScreen assay, binds to LC3B selectively based on K49, potently inhibits autophagy.
LC3in-C42 does not show any impact on γ-aminobutyric acid receptor-associated proteins (GABARAPs).
LC3in-C42 (5 uM) can completely disrupt the interaction between LC3A/B and P62, but not other four LC3 family proteins.
LC3in-C42 (10 uM) attenuates LC3-I/II lipidation in a dose-dependent manner in HeLa cells when the autophagy is induced, significantly inhibits P62 degradation.
LC3in-C42 (2.5 uM) almost completely impairs autophagosome and autophagolysosome formation in HeLa cells.

物理化学性质&存储条件

分子量	394.30
分子式	C19H21Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5,6-Dichloro-1H-indol-4-yl)-2-(((2-(dimethylamino)ethyl)amino)methylene)cyclohexane-1,3-dione

参考文献

1. Zhenfei Zhou, et al. J Med Chem. 2024 Jul 15. doi: 10.1021/acs.jmedchem.4c00898

LC3in-C42

生物&药学活性

物理化学性质&存储条件

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LC3in-C42

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物理化学性质&存储条件

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