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LH2-051

Chemical Structure : LH2-051

CAS No.: 2358754-22-8

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LH2-051 (LH 2-051)

货号: PC-28579Not For Human Use, Lab Use Only.

LH2-051 is a lysosome-enhancing compound that promote TFEB (transcription factor EB) activation and lysosome biogenesis, significantly inhibits the function of the dopamine transporter (DAT) and subsequently promotes lysosome biogenesis via DAT-CDK9-TFEB axis.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LH2-051 is a lysosome-enhancing compound that promote TFEB (transcription factor EB) activation and lysosome biogenesis, significantly inhibits the function of the dopamine transporter (DAT) and subsequently promotes lysosome biogenesis via DAT-CDK9-TFEB axis.
LH2-051 induces TFEB-dependent lysosome biogenesis.
LH2-051 significantly promotes the nuclear translocation of TFEB-EGFP in a dose- and time-dependent manners.
LH2-051 binds directly with DAT and inhibits DAT function, inhibits DAT-mediated dopamine uptake with IC50 of 4.67 uM.
LH2-051 induces TFEB nuclear translocation through repressing CDK9.
LH2-051 induces the translocation of DAT from the plasma membrane onto lysosomal membranes.
LH2-051 induces a reduction of brain Aβ plaques and improves the memory of APP/PS1 mice.

物理化学性质&存储条件

分子量 434.58
分子式 C27H34N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(1H-Indol-3-yl)ethyl)-6,7-dimethoxy-2-((tetrahydro-2H-pyran-4-yl)methyl)-1,2,3,4-tetrahydroisoquinoline

参考文献

1. Yin L, et al. Alzheimers Dement. 2023 Apr;19(4):1343-1357.

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