JS-017 | A2E degrader | Probechem Biochemicals

Chemical Structure : JS-017

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JS-017 (JS017)

货号: PC-20502Not For Human Use, Lab Use Only.

JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM.

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生物&药学活性

JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM.
JS-017 effectively degraded A2E in ARPE-19 cells and consequently suppressed the activation of the NF-κB signaling pathway and expression of inflammatory and apoptosis genes induced by blue light (BL).
JS-017 induced LC3-II formation and improved autophagic flux in ARPE-19 cells.
The A2E degradation activity of JS-017 was required for A2E degradation mediated by JS-017.
JS-017 exhibited an improvement in BL-induced retinal damage measured through fundus examination in an in vivo retinal degeneration mouse model.
JS-017 protected human retinal pigment epithelium (RPE) cells from A2E and BL-induced damage by degrading A2E via the activation of autophagy.

物理化学性质&存储条件

分子量	285.34
分子式	C17H19NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-allyl-2-methoxyphenyl)-5-((allyloxy)methyl)isoxazole

参考文献

1. Young Chae Shin, et al. Biochem Pharmacol. 2023 Apr 4;211:115534.

JS-017 (JS017)

生物&药学活性

物理化学性质&存储条件

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JS-017 (JS017)

生物&药学活性

物理化学性质&存储条件

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