Autophagy inducer D61 | Autophagy inducer | Probechem Biochemicals

Chemical Structure : Autophagy inducer D61

加入收藏

Autophagy inducer D61 (SEW06622)

货号: PC-38562Not For Human Use, Lab Use Only.

Autophagy inducer D61 is a small molecule autophagy inducer with antibacterial activity, induces LC3II and promotes aggregation of LC3II near Salmonella.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Autophagy inducer D61 is a small molecule autophagy inducer with antibacterial activity, induces LC3II and promotes aggregation of LC3II near Salmonella.
D61 (25 uM) reduced the bacterial load (GFP signal in RAW 264.7 macrophages) by 20-fold, with IC50 of 1.3 μM in the SAFIRE assay.
D61 antibacterial activity depends on the VPS34 complex and on ATG5.
D61 also reduced Salmonella load in the spleens and livers of infected mice.
D61 antibacterial activity in macrophages is synergistic with the antibiotic chloramphenicol but that this synergy is largely independent of the known autophagy-stimulating activity of chloramphenicol.
Salmonella enterica is a natural bacterial pathogen of humans and animals that causes systemic infection or gastroenteritis.

物理化学性质&存储条件

分子量	338.451
分子式	C21H26N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(1-benzylpiperidin-4-yl)-1-(2,3-dimethoxyphenyl)methanimine

参考文献

1. Nagy TA, et al. Antimicrob Agents Chemother. 2019 Oct 7;63(12):e01536-19.

Autophagy inducer D61 (SEW06622)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Autophagy inducer D61 (SEW06622)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.