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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-BAR502
BAR502

Chemical Structure : BAR502

CAS No.: 1612191-86-2

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BAR502 (NorECDCOH, BAR-502, BAR 502)

货号: PC-20485Not For Human Use, Lab Use Only.

BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively.
BAR502 potently inhibits binding of LIF to LIFR with an IC50 of 3.8 uM.
BAR502 protected against liver damage caused by HFD by promoting the browning of adipose tissue.
BAR502 partially protected against liver damage caused by Western diet.
The combination of BAR502 and UDCA reversed the pro-atherogenic lipid profile and completely reversed the histopathology damage, attenuating liver steatosis, ballooning, inflammation and fibrosis.

物理化学性质&存储条件

分子量 392.62
分子式 C25H44O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-4-hydroxybutan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

参考文献

1. Marchianò S, et al. Sci Rep. 2023 Jan 28;13(1):1602.

2. Carino A, et al. Sci Rep. 2017 Feb 16;7:42801.

3. Festa C. et al. J Med Chem. 57, 8477–95 (2014).

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