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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-BMS-986339
BMS-986339

Chemical Structure : BMS-986339

CAS No.: 2477873-64-4

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BMS-986339 (BMS986339)

货号: PC-47028Not For Human Use, Lab Use Only.

BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo.

    物理化学性质&存储条件

    分子量 643.724
    分子式 C35H41F4N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1s,3s)-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-N-(4'-(2-hydroxypropan-2-yl)-[1,1'-biphenyl]-3-yl)-3-(trifluoromethyl)cyclobutane-1-carboxamide

    参考文献

    1. Susheel J Nara, et al. J Med Chem. 2022 Jun 15. doi: 10.1021/acs.jmedchem.2c00165.

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