欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-BMS-986318
BMS-986318

Chemical Structure : BMS-986318

CAS No.: 2314378-09-9

加入收藏

BMS-986318 (BMS 986318)

货号: PC-20976Not For Human Use, Lab Use Only.

BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.
BMS-986318 exhibits EC50 of 350 nM in FXR steroid receptor coactivator 1 (SRC-1) recruitment assays.
BMS-986318 (10, 30, and 100 mg/kg) demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.

物理化学性质&存储条件

分子量 615.43
分子式 C30H23Cl2F3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=NC2=CC=C(N(CC3)CCC43CC(C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)=C4)C=C2C(C(F)(F)F)=C1)O

参考文献

1. Carpenter J, et al. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: