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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-GSK2324
GSK2324

Chemical Structure : GSK2324

CAS No.: 1020567-30-9

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GSK2324 (GSK 2324)

货号: PC-60080Not For Human Use, Lab Use Only.

GSK2324 (GSK 2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK2324 (GSK 2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.
    GSK2324 lowers body weight gain and serum glucose in a DIO mouse model of diabetes.

    物理化学性质&存储条件

    分子量 533.405
    分子式 C29H22Cl2N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)quinoline-2-carboxylic acid

    参考文献

    1. Bass JY, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.

    2. de Aguiar Vallim TQ, et al. Circ Res. 2013 Jun 7;112(12):1602-12.

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