FXR-sHE modulator 57 |CAS:2129523-23-3 Probechem Biochemicals

Chemical Structure : DM509

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DM509 (FXR-sHE modulator 57, DM-509)

货号: PC-61057Not For Human Use, Lab Use Only.

DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).

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生物&药学活性

DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
DM509 demonstrates antisteatotic and antifibrotic effects and potential for nonalcoholic steatohepatitis (NASH) management with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics.

物理化学性质&存储条件

分子量	394.914
分子式	C19H23ClN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(tert-Butyl)-N-(2-chloro-4-(methylsulfonamido)benzyl)-benzamide

参考文献

1. Schmidt J, et al. J Med Chem. 2017 Sep 28;60(18):7703-7724.

DM509 (FXR-sHE modulator 57, DM-509)

生物&药学活性

物理化学性质&存储条件

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DM509 (FXR-sHE modulator 57, DM-509)

生物&药学活性

物理化学性质&存储条件

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