REV7-IN-1 (REV7/REV3L-IN-1)

Chemical Structure : REV7-IN-1

CAS No.: 1979192-13-6

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货号: PC-28470Not For Human Use, Lab Use Only.

REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin.

物理化学性质&存储条件

分子量	371.46
分子式	C19H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1-Acetylpiperidin-4-yl)methyl)-5-(5-methylfuran-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one

参考文献

1. Actis ML, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.