REV7 inhibitor C10 | REV7 inhibitor | Probechem Biochemicals

Chemical Structure : REV7 inhibitor C10

加入收藏

REV7 inhibitor C10 (Compound 10)

货号: PC-28474Not For Human Use, Lab Use Only.

REV7 inhibitor C10 (Compound 10) is a small-molecule inhibitor targeting the REV3-binding interface of REV7 (MAD2L2) and disrupting the REV7-REV3 protein-protein interaction (IC50=3.9 uM) within DNA polymerase ζ (Pol ζ).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

REV7 inhibitor C10 (Compound 10) is a small-molecule inhibitor targeting the REV3-binding interface of REV7 (MAD2L2) and disrupting the REV7-REV3 protein-protein interaction (IC50=3.9 uM) within DNA polymerase ζ (Pol ζ).
C10 sensitized HCT116 and HT-29 CRC cells to the microtubule-disrupting agent colchicine, resulting in markedly reduced clonogenic survival.
C10 does not substantially enhance sensitivity to cisplatin.
Combined C10 and colchicine treatment is associated with pronounced alterations in mitotic and post-mitotic nuclear morphology, including condensed/mitotic-like and multinucleated configurations, and increased micronucleus formation.
Combined C10 and colchicine treatment also increases the frequency of cells containing multiple γ-tubulin-positive foci, consistent with disrupted centrosome-associated organization in HT-29 cells.

物理化学性质&存储条件

分子量	510.67
分子式	C27H30N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-(diethylcarbamoyl)-4-methyl-2-(2-phenyl-2-(phenylthio)acetamido)thiophene-3-carboxylate

参考文献

1. Guyette M, et al. bioRxiv [Preprint]. 2026 Sep 30:2026.09.29.755408.

REV7 inhibitor C10 (Compound 10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

REV7 inhibitor C10 (Compound 10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.