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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-MM927
MM927

Chemical Structure : MM927

CAS No.: 3065567-21-4

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MM927 (MM-927, MM 927)

货号: PC-25300Not For Human Use, Lab Use Only.

NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL (nuclear valosin-containing protein-like) with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL (nuclear valosin-containing protein-like) with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM.
    MM927 also inhibits mouse NVL with an IC50 of 0.207 µM。
    MM927 is a structurally related compound with improved metabolic stability compared with MM17.
    MM927 reduces viability through the same mechanism as MM17, by blocking 60S biogenesis via NVL inhibition.
    MM927 induces half-mer polysomes in polysome profiles and arrests 60S ribosome biogenesis in the nucleolus.
    MM927 also triggers cell cycle arrest at both the G1/S and G2/M transitions, mirroring the effects of MM17, with G1/S arrest partially and G2/M arrest fully dependent on p53.
    MM927 (35 mg/kg, i.p.) inhibits colorectal and leukemia tumor xenograft growth in vivo without overt toxicity.
    MM927 inhibit ribosome biogenesis without causing DNA damage.

    物理化学性质&存储条件

    分子量 487.51
    分子式 C26H18FN3O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(10-(but-2-yn-1-yl)-3-fluoro-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide

    参考文献

    1. Guo HH, et al. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.

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