Polθ ATPase inhibitor XL-20

Chemical Structure : Polθ ATPase inhibitor XL-20

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货号: PC-26687Not For Human Use, Lab Use Only.

XL-20 is a potent, selective orally bioavailable selenium-containing DNA polymerase theta (Polθ) inhibitor with IC50 of 4.3 nM for Polθ ATPase.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

XL-20 is a potent, selective orally bioavailable selenium-containing DNA polymerase theta (Polθ) inhibitor with IC50 of 4.3 nM for Polθ ATPase.
XL-20 demonstrates synergistic antitumor efficacy with PARP inhibition both in HR-deficient MDA-MB-436 cells and in vivo xenograft models.
XL-20 also significantly activates the cGAS-STING pathway and upregulates PD-L1, supporting its combination potential with immunotherapy.

物理化学性质&存储条件

分子量	522.40
分子式	C24H18FN5O3Se
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((4-cyanophenoxy)methyl)-1,3,4-selenadiazol-2-yl)-4-(2-fluoro-6-methoxyphenyl)-6-methylnicotinamide

参考文献

1. Luyu Ma, et al. Eur J Med Chem. 2026 Apr 28:313:118887.