SGC-CK2-1

Chemical Structure : SGC-CK2-1

CAS No.: 2470424-39-4

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货号: PC-72809Not For Human Use, Lab Use Only.

SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).
Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
Chemical probe SGC-CK2-1 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.

物理化学性质&存储条件

分子量	375.436
分子式	C20H21N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-2-methylphenyl)propionamide

参考文献

1. Carrow I Wells, et al. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10.

2. Xuan Yang, et al. bioRxiv. 2022 Jan 4;2022.01.03.474779.

SGC-CK2-1

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