| Cat. No. |
Product Name |
Information |
| PC-28450 |
LH846
Circadian modulator, CK1δ inhibitor
|
LH846 is a small molecule modulator of circadian rhythms, inhibits CKIδ (CK1δ) with an IC50 of 290 nM, CKIα with an IC50 of 2.5 μM, CKIε with an IC50 of 1.3 μM and has no effect on CK2, lengthens circadian period. |
| PC-28449 |
NCC007
Circadian modulator, CK1α/CKIδ inhibitor
|
NCC007 is a small molecule CKIα and CKIδ dual inhibitor with IC50 of 1.8 and 3.6 uM respectively, modulates mammalian circadian rhythms with strong period effects (0.32 μM for 5 h period lengthening) in cell-based circadian assays. |
| PC-28448 |
Longdaysin
Circadian modulator, CK1δ/CKIδ inhibitor
|
Longdaysin is a potent modulator of circadian rhythms targeting protein kinases CKIδ, CKIα, and ERK2, inhibits CKIα-mediated phosphorylation stimulated degradation of a clock protein PER1, drastically lengthens circadian period in vivo, also inhibits Wnt/β-catenin signaling and exhibits antitumor activity against breast cancer. |
| PC-28447 |
THBZA
Circadian modulator, CK1δ/CKIδ inhibitor
|
THBZA is a circadian period-lengthening compound that preferentially inhibits casein kinase I (CKIδ, CK1δ) over CKIα with IC50 of 3.0 uM and 8.8 uM respectively. |
| PC-27914 |
GO847
CK2 inhibitor
|
GO847 is a potent, specfic and orally bioavailable Casein Kinase 2 (CK2) inhibitor with IC50 of 40.2 nM. |
| PC-27633 |
DMAT
CK2 inhibitor
|
DMAT is a potent, selective and cell permeable inhibitor of Casein Kinase 2 (CK2) with Ki of 40 nM, does not inhibit CK1 up to 200 uM. |
| PC-25618 |
APL-5125
CK2α inhibitor
|
APL-5125 is a highly potent, selective, ATP-competitive casein kinase 2α (CK2α) inhibitor with IC50 of 0.348 nM and Ki of 0.095 nM in ADP-GloTM Assays, >300-fold selective over CLK2 and DAPK3. |
| PC-25510 |
CK2 inhibitor TBB
CK2 inhibitor
|
TBB (4,5,6,7-tetrabromobenzotriazole) is a potent, cell-permeable and ATP-competitive CK2 inhibitor with IC50 of 0.15 uM and 1.6 uM for rat liver CK2 and human CK2 respectively. |
| PC-24840 |
KDX1381
CK2α inhibitor
|
KDX1381 is a potent, selective bivalent CK2α inhibitor with IC50 of 17 nM, selecitve over a panel of over 400 protein and lipid kinases. |
| PC-24756 |
CK2 bivalent inhibitor Biv5
CK2 inhibitor
|
CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells. |
| PC-24728 |
PF-4800567
CK1ε inhibitor
|
PF-4800567 is a potent, selective inhibitor of casein kinase 1 epsilon (CK1epsilon, CK1ε) with IC50 of 32 nM, >20-fold selectivity over CK1δ. |
| PC-21783 |
AB668
CK2 inhibitor
|
AB668 is a selective, bivalent Casein Kinase 2 (CK2) inhibitor targeting the ATP site and the αD pocket, AB668 inhibits the CK2 holoenzyme with Ki value of 41 nM (IC50=65 nM). |
