THBZA

Chemical Structure : THBZA

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货号: PC-28447Not For Human Use, Lab Use Only.

THBZA is a circadian period-lengthening compound that preferentially inhibits casein kinase I (CKIδ, CK1δ) over CKIα with IC50 of 3.0 uM and 8.8 uM respectively.

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生物&药学活性

THBZA is a circadian period-lengthening compound that preferentially inhibits casein kinase I (CKIδ, CK1δ) over CKIα with IC50 of 3.0 uM and 8.8 uM respectively.
THBZA lengthens cellular circadian period in human U2OS cells.
THBZA lengthens circadian period in Per2::Luc knock-in mouse tissue explants.
THBZA inhibits CKI with moderate CKIδ selectivity (2.9 fold over CKIα).

物理化学性质&存储条件

分子量	309.34
分子式	C16H11N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(benzo[d]isoxazol-3-yl)-N-(benzo[d]thiazol-2-yl)acetamide

参考文献

1. Toda T, et al. Biochem Biophys Res Commun. 2026 Sep 28;838:154649.

THBZA

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THBZA

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