DMAT

Chemical Structure : DMAT

CAS No.: 749234-11-5

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货号: PC-27633Not For Human Use, Lab Use Only.

DMAT is a potent, selective and cell permeable inhibitor of Casein Kinase 2 (CK2) with Ki of 40 nM, does not inhibit CK1 up to 200 uM.

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10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

DMAT is a potent, selective and cell permeable inhibitor of Casein Kinase 2 (CK2) with Ki of 40 nM, does not inhibit CK1 up to 200 uM.
DMAT inhibits caspase-mediated killing of human breast cancer cells with acquired resistance to antiestrogens.
DMAT reduces HCC growth by interference with NFκB- and Wnt-signaling.
DMAT induces reactive oxygen species and DNA double strand breaks.

物理化学性质&存储条件

分子量	476.79
分子式	C9H7Br4N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole

参考文献

1. Pagano MA, et al. Biochem Biophys Res Commun. 2004 Sep 3;321(4):1040-4.

2. Yde CW, et al. Cancer Lett. 2007 Oct 28;256(2):229-37.

3. Schneider CC, et al. Oncol Rep. 2009 Jun;21(6):1593-7.

DMAT

生物&药学活性

物理化学性质&存储条件

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