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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-CIGB-300
CIGB-300

Chemical Structure : CIGB-300

CAS No.: 1072877-99-6

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CIGB-300 (P15-Tat, GRKKRRQRRRPPQ-X-CWMSPRHLGTC-acid disulphide bridged Cys15-Cys25)

货号: PC-72167Not For Human Use, Lab Use Only.

CIGB-300 (P15-Tat) is a cell-permeable cyclic peptide that modulates CK2 (CSNK2) activity by binding to the phosphoacceptor site on CK2 targets, abrogates the CK2 phosphorylation by blocking recombinant substrates in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CIGB-300 (P15-Tat) is a cell-permeable cyclic peptide that modulates CK2 (CSNK2) activity by binding to the phosphoacceptor site on CK2 targets, abrogates the CK2 phosphorylation by blocking recombinant substrates in vitro.
    CIGB-300 (P15-Tat) induced apoptosis as evidenced by rapid caspase activation and cellular cytotoxicity in a variety of tumor cell lines (HSCLC H-82 cell IC50=20 uM).
    CIGB-300 (P15-Tat) demonstrated substantial regression of the tumor mass C57BL6 mice bearing day 7-established solid tumors.
    CIGB-300 (P15-Tat) reduced breast cancer cell growth in MDA-MB-231, MCF-7 and F3II cells, exerting a pro-apoptotic action and cell cycle arrest. CIGB-300 decreased cell adhesion, migration and clonogenic capacity of malignant cells.
    CIGB-300 may interfere with the SARS-CoV-2 life cycle within infected human cells.

    物理化学性质&存储条件

    分子量 3060.60
    分子式 C127H215N53O30S3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in MDSO
    Chemical Name/SMILES

    GRKKRRQRRRPPQ-X-CWMSPRHLGTC-acid disulphide bridged Cys15-Cys25

    参考文献

    1. Perea SE, et al. Mol Cell Biochem. 2008 Sep;316(1-2):163-7.

    2. Silvio E Perea, et al. Cancer Res. 2004 Oct 1;64(19):7127-9.

    3. Miranda J, et al. Mol Med. 2021 Dec 20;27(1):161.

    4. Gottardo MF, et al. Sci Rep. 2020 Sep 7;10(1):14689.

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