ON108110 |CAS:1415599-79-9 Probechem Biochemicals

Chemical Structure : ON108110

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ON108110 (ON-108110, ON 108110)

货号: PC-36054Not For Human Use, Lab Use Only.

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).

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生物&药学活性

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).
ON108110 reduces replication of influenza A virus in a dose-dependent manner by suppressing viral RNA synthesis, also inhibits other viruses including vesicular stomatitis virus and Newcastle disease virus.
ON108110 inhibits MCL and T-ALL cell growth (GI50 values of 0.2-3 uM), inhibits CK2 and CDK4/6 mediated oncogenic signaling.

物理化学性质&存储条件

分子量	374.342
分子式	C17H11FN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-((6-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-ylidene)methyl)-2-nitrophenyl acetate

参考文献

1. Padgaonkar A, et al. Oncotarget. 2018 Dec 28;9(102):37753-37765.

2. Martinez-Gil L, et al. Antiviral Res. 2013 Oct;100(1):29-37.

ON108110 (ON-108110, ON 108110)

生物&药学活性

物理化学性质&存储条件

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ON108110 (ON-108110, ON 108110)

生物&药学活性

物理化学性质&存储条件

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