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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-Epiblastin A
Epiblastin A

Chemical Structure : Epiblastin A

CAS No.: 16470-02-3

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Epiblastin A (Casein kinase 1 inhibitor)

货号: PC-38526Not For Human Use, Lab Use Only.

Epiblastin A is a small molecule ATP-competitive casein kinases 1 (CK1) inhibitor with IC50 values of 0.8, 3.7 and 3.8 uM for CK1δ, CK1ε and CK1α, engages CK1 isoenzymes in cell lysate and induces efficient conversion of mouse epiblast stem cells (EpiSCs) to embryonic stem cells (cESCs).

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Epiblastin A is a small molecule ATP-competitive casein kinase 1 (CK1) inhibitor with IC50 values of 0.8, 3.7 and 3.8 uM for CK1δ, CK1ε and CK1α, engages CK1 isoenzymes in cell lysate and induces efficient conversion of mouse epiblast stem cells (EpiSCs) to embryonic stem cells (cESCs).
Epiblastin A elicits significant dose-dependent inhibition of the viability of HT29, HCT116, and DLD1 cells with a 48 h IC50 of 6.8, 5.0, and 3.2 μM, respectively.
Epiblastin A attenuated expression of CK1α in CRC primary cultures and PDX samples.
Epiblastin A suppressed tumor volume and tumor weight in a CK1α-dependent manner in DLD1-derived tumor xenograft mice.

物理化学性质&存储条件

分子量 287.71
分子式 C12H10CIN7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(3-Chlorophenyl)-2,4,7-pteridinetriamine

参考文献

1. Ursu A, et al. Cell Chem Biol. 2016 Apr 21;23(4):494-507.

2. Ren F, et al. Transl Cancer Res. 2020 Mar;9(3):1903-1913.

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