CK2 inhibitor KN2 | CK2 inhibitor | Probechem Biochemicals

Chemical Structure : CK2 inhibitor KN2

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CK2 inhibitor KN2 (KN2)

货号: PC-72228Not For Human Use, Lab Use Only.

CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2).

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生物&药学活性

CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2).
KN2 inhibits CK2α- and CK2α′-based CK2 holoenzymes with IC50 of 19.3 nM (CK2α2β2) and 15.6 nM (CK2α′2β2) at 100 uM ATP.
KN2 downregulated the CK2-dependent phosphorylation level of Akt phosphorylation at Ser129 (p-Akt S129).

物理化学性质&存储条件

分子量	776.971
分子式	C23H22Br4Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3,4-dichlorophenethyl)-N4-(4-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-1-yl)butyl)succinamide

参考文献

1. Dirk Lindenblatt, et al. J Med Chem. 2022 Jan 27;65(2):1302-1312.

CK2 inhibitor KN2 (KN2)

生物&药学活性

物理化学性质&存储条件

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CK2 inhibitor KN2 (KN2)

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物理化学性质&存储条件

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