| Cat. No. |
Product Name |
Information |
| PC-23748 |
MMRi36
MDM2-MDM4 E3 ligase activator
|
MMRi36 is a MDM2-MDM4 E3 heterodimer E3 ligase activator, binds and stabilizes MDM2-MDM4 RING domain heterodimer (Kd=308 nM, MST assay), promotes proteasomal degradation of MDM2/MDM4 proteins in cells. |
| PC-23521 |
TRAP-1
p53 activator
|
TRAP-1 is a small molecule chemical inducer of proximity that activates mutant p53, engages mutant p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. |
| PC-23284 |
PG3-Oc
p53 activator, ATF4 activator
|
PG3-Oc is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 31 nM. |
| PC-23283 |
PG3
p53 activator, ATF4 activator
|
PG3 is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 through ISR via kinase HRI (Heme-Regulated Inhibitor) and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 36 nM. |
| PC-22936 |
RITA
p53/HDM-2 inhibitor
|
RITA is a small molecule inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2), binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2. |
| PC-22898 |
MX69-102
MDM2 degrader
|
MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM. |
| PC-21746 |
NSC146109
MDM4 inhibitor
|
NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |
| PC-21238 |
DS-3032 tosylate hydrate
MDM2-p53 inhibitor
|
Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
| PC-20688 |
MMRi71
MDM2-MDM4 E3 ligase inhibitor
|
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells. |
| PC-20687 |
MMRi67
MDM2-MDM4 E3 ligase inhibitor
|
MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM. |
| PC-62080 |
RETRA hydrochloride
|
RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
| PC-62079 |
RETRA hydrobromide
|
RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
