| Cat. No. |
Product Name |
Information |
| PC-45613 |
Tenovin-3
p53 activator
|
Tenovin-3 is a sirtuin inhibitor that increases p53 levels in MCF-7 cells. |
| PC-45845 |
Nutlin-3
p53-MDM2 inhibitor
|
Nutlin-3 (Nutlin 3) is a potent and selective Mdm2 inhibitor with IC50 of 90 nM. |
| PC-42750 |
RG7112
p53-MDM2 inhibitor
|
RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM). |
| PC-45588 |
SAR405838
p53-MDM2 inhibitor
|
SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM. |
| PC-44349 |
Nutlin-3b
p53-MDM2 inhibitor
|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
| PC-42287 |
MX69
MDM2 inhibitor
|
MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM. |
| PC-45124 |
RO8994
p53-MDM2 inhibitor
|
RO8994 (RO 8994) is a highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM. |
| PC-45048 |
Pifithrin-β hydrobromide
p53 inhibitor
|
Pifithrin-β hydrobromide is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-27805 |
NSC146109 hydrochloride
MDMX inhibitor, p53 activator
|
NSC146109 (XI-011) hydrochloride is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |
| PC-27559 |
MI-888
MDM2 inhibitor
|
MI-888 is an orally active MDM2 inhibitor with Ki of 0.44 nM, inhibit the MDM2-p53 interaction. |
| PC-27558 |
MI-1061
MDM2 inhibitor
|
MI-1061 is a potent and efficacious MDM2 inhibitor with binding IC50 of 4.4 nM and Ki of 0.16 nM. |
