| Cat. No. |
Product Name |
Information |
| PC-45047 |
Pifithrin-β
p53 inhibitor
|
Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53. |
| PC-25767 |
PhiKan083
p53 Y220C reactivator
|
PhiKan083 (PhiKan-083) is a specific reactivator and stabilizer and reactivator of p53 Y220C mutant with dissociation constant of 150 uM, binds to the surface cavity and stabilizes p53 Y220C. |
| PC-25766 |
JC744
p53 Y220C reactivator
|
JC744 is a small molecule stabilizer and reactivator of p53 Y220C mutant with Kd of 320 nM. |
| PC-25763 |
PK5196
p53 Y220C reactivator
|
PK5196 is a small molecule p53 Y220C reactivator and p53 Y220C binder (SPR Kd=6.88 uM), effectively increase the thermal stability of p53 Y220C protein. |
| PC-25429 |
Idasanutlin
p53-MDM2 inhibitor
|
Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM in HTRF binding assays, inhibits wt-p53 cancer cell lines (SJSA1, RKO, HCT116) with mean IC50 of 0.03 uM. |
| PC-24496 |
NVP-CGM097
MDM2 inhibitor
|
NVP-CGM097 is potent and selective MDM2 inhibitor with Ki of 1.3 nM (human MDM2, HDM2), inhibits p53-MDM2 protein-protein interaction with IC50 of 1.7 nM in TR-FRET assays. |
| PC-24085 |
Pifithrin-μ
p53 inhibitor
|
Pifithrin-μ is a specific small molecule inhibitor of p53 and HSP70, shows antitumor and neuroprotective activity. |
| PC-23748 |
MMRi36
MDM2-MDM4 E3 ligase activator
|
MMRi36 is a MDM2-MDM4 E3 heterodimer E3 ligase activator, binds and stabilizes MDM2-MDM4 RING domain heterodimer (Kd=308 nM, MST assay), promotes proteasomal degradation of MDM2/MDM4 proteins in cells. |
| PC-23521 |
TRAP-1
p53 activator
|
TRAP-1 is a small molecule chemical inducer of proximity that activates mutant p53, engages mutant p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. |
| PC-23284 |
PG3-Oc
p53 activator, ATF4 activator
|
PG3-Oc is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 31 nM. |
| PC-23283 |
PG3
p53 activator, ATF4 activator
|
PG3 is a small-molecule that restores p53 pathway-signaling in tumor cells with mutant-p53, activates ATF4 through ISR via kinase HRI (Heme-Regulated Inhibitor) and upregulates p53 target genes, inhibits cell viabiltiy of p53 mutation R273H (HT29 cell) with IC50 of 36 nM. |
| PC-22936 |
RITA
p53/HDM-2 inhibitor
|
RITA is a small molecule inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2), binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2. |
