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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-MX69
MX69

Chemical Structure : MX69

CAS No.: 1005264-47-0

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MX69 (MDM2 inhibitor, MX-69)

货号: PC-42287Not For Human Use, Lab Use Only.

MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MX69 is a specific inhibitor of MDM2 inhibitor with Kd of 2.75 uM.
MX69 induces ubiquitination of endogenous MDM2, results in activation of p53 and inhibition of XIAP, and induces cell apoptosis and death in cancer cells.
MX69 shows significant apoptotic and anti-proliferative effects on MDM2-expressing cancer cells both in vitro and in vivo, with minimal inhibitory effect on normal human hematopoiesis.

物理化学性质&存储条件

分子量 474.57134
分子式 C27H26N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

4-{8-[(3,4-Dimethylphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid

参考文献

1. Gu L, et al. Cancer Cell. 2016 Oct 10;30(4):623-636.

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