RG7112 |CAS:939981-39-2 Probechem Biochemicals

Chemical Structure : RG7112

CAS No.: 939981-39-2

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RG7112 (RG-7112;RO5045337)

货号: PC-42750Not For Human Use, Lab Use Only.

RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

RG7112 (RO5045337) is a potent and selective inhibitor of p53-MDM2 interaction, binds MDM2 with high affinity (Kd=11 nM).
RG7112 stabilizes p53 and activates the p53 pathway, leading to cell cycle arrest, apoptosis, and inhibition or regression of human tumor xenografts. orally bioactive.

物理化学性质&存储条件

分子量	727.7831
分子式	C38H48Cl2N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]-

参考文献

1. Tovar C, et al. Cancer Res. 2013 Apr 15;73(8):2587-97.

2. Andreeff M, et al. Clin Cancer Res. 2016 Feb 15;22(4):868-76.

3. Vu B, et al. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9.

RG7112 (RG-7112;RO5045337)

生物&药学活性

物理化学性质&存储条件

参考文献

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RG7112 (RG-7112;RO5045337)

生物&药学活性

物理化学性质&存储条件

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